Robert Zahler : rechercher sur Z-Library

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1

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Karnail S. Atwal, Steven V. O’Neil, Saleem Ahmad, Lidia Doweyko, Mark Kirby, Charles R. Dorso, Gamini Chandrasena, Bang-Chi Chen, Rulin Zhao, Robert Zahler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 120 KB

english, 2006

2

The vascular barrier-protecting hawthorn extract WSÂ® 1442 raises endothelial calcium levels by inhibition of SERCA and activation of the IP3 pathway

Willer, Elisabeth A., Malli, Roland, Bondarenko, Alexander I., Zahler, Stefan, Vollmar, Angelika M., Graier, Wolfgang F., FÃ¼rst, Robert

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2012

Langue:

english

Fichier:

PDF, 716 KB

english, 2012

3

Heterogeneous signal intensity in magnetic resonance images of hypertrophied left ventricular myocardium

Raphael Zahler, David Chelmow, John Gore, Kenneth Wilkens, Christopher Pope, H.Disk Sostman, Roderick Meese, Rosa Negro-Vilar, Robert J. Herfkens, Frans J. Wackers, Barry L. Zaret

Journal:

Magnetic Resonance Imaging

Année:

1989

Langue:

english

Fichier:

PDF, 2.90 MB

english, 1989

4

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase

Gregory S Bisacchi, William A Slusarchyk, Scott A Bolton, Karen S Hartl, Glenn Jacobs, Arvind Mathur, Wei Meng, Martin L Ogletree, Zulan Pi, James C Sutton, Uwe Treuner, Robert Zahler, Guohua Zhao, St

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 279 KB

english, 2004

5

Design, synthesis, and structure–activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARα/γ agonists

Xiang-Yang Ye, Yi-Xin Li, Dennis Farrelly, Neil Flynn, Liqun Gu, Kenneth T. Locke, Jonathan Lippy, Kevin O’Malley, Celeste Twamley, Litao Zhang, Denis E. Ryono, Robert Zahler, Narayanan Hariharan, Pet

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 220 KB

english, 2008

6

Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes

Robert P. Brigance, Wei Meng, Aberra Fura, Thomas Harrity, Aiying Wang, Robert Zahler, Mark S. Kirby, Lawrence G. Hamann

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 285 KB

english, 2010

7

Reactions of the dimethyl cyclobutane-1,2-dicarboxylate dianion. A simple synthesis of 1,2-dihydrocyclobuta [b] naphthalene-3, 8-dione

Peter J. Garratt, Robert Zahler

Journal:

Tetrahedron Letters

Année:

1979

Langue:

english

Fichier:

PDF, 148 KB

english, 1979

8

Vicinal diester dianions. Annelation with allylic and benzylic αω-dihalides. Synthesis of tricyclobuta[1,2:3,4:6,7]naphthalene

Kevin G. Bilyard, Peter J. Garratt, Alan J. Underwood, Robert Zahler

Journal:

Tetrahedron Letters

Année:

1979

Langue:

english

Fichier:

PDF, 174 KB

english, 1979

9

A practical method for the preparation of α′-chloroketones of N-carbamate protected-α-aminoacids

Ping Chen, Peter T.W. Cheng, Steven H. Spergel, Robert Zahler, Xuebao Wang, John Thottathil, Joel C. Barrish, Richard P. Polniaszek

Journal:

Tetrahedron Letters

Année:

1997

Langue:

english

Fichier:

PDF, 230 KB

english, 1997

10

Optically active fluorinated cyclobutane nucleoside analogs with potent anti-herpes activity

Saleem Ahmad, Gregory S. Bisacchi, A.Kirk Field, Glenn A. Jacobs, A.Vickie Tuomari, Bridget McGeever-Rubin, Gregory D. Vite, Robert Zahler

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1993

Langue:

english

Fichier:

PDF, 301 KB

english, 1993

11

Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro

Stefan Zahler, Johanna Liebl, Robert Fürst, Angelika M. Vollmar

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 609 KB

english, 2010

12

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

Johanna Liebl, Vladimir Krystof, György Vereb, Lili Takács, Miroslav Strnad, Paul Pechan, Libor Havlicek, Marek Zatloukal, Robert Fürst, Angelika M. Vollmar, Stefan Zahler

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 658 KB

english, 2011

13

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

James C Sutton, Scott A Bolton, Malcolm E Davis, Karen S Hartl, Bruce Jacobson, Arvind Mathur, Martin L Ogletree, William A Slusarchyk, Robert Zahler, Steven M Seiler, Gregory S Bisacchi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 399 KB

english, 2004

14

Roscovitine blocks leukocyte extravasation by inhibition of cyclin-dependent kinases 5 and 9

Nina Berberich, Bernd Uhl, Jos Joore, Ulrike K Schmerwitz, Bettina A Mayer, Christoph A Reichel, Fritz Krombach, Stefan Zahler, Angelika M Vollmar, Robert Fürst

Journal:

British Journal of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2011

15

Kinetics of drug effect by distributed lags analysis: An application to cocaine

Zahler, Raphael, Wachtel, Paul, Jatlow, Peter, Byck, Robert

Journal:

Clinical Pharmacology & Therapeutics

Année:

1982

Langue:

english

Fichier:

PDF, 451 KB

english, 1982

16

Accounts in Drug Discovery Volume 740 || Chapter 1. The Discovery of the Dipeptidyl Peptidase-4 (DPP4) Inhibitor Onglyza™: From Concept to Market

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2010

17

Accounts in Drug Discovery Volume 154 ||

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 38 KB

english, 2010

18

Accounts in Drug Discovery Volume 154 || Front Matter

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 77 KB

english, 2010

19

Accounts in Drug Discovery Volume 467 || Chapter 2. The Discovery of Vorapaxar (SCH 530348), a Thrombin Receptor (Protease Activated Receptor-1) Antagonist with Potent Antiplatelet Effects

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 3.62 MB

english, 2010

20

Accounts in Drug Discovery Volume 4725 || Chapter 4. The Discovery of OSI-906, a Small-molecule Inhibitor of the Insulin-like Growth Factor-1 and Insulin Receptors

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 17.57 MB

english, 2010

21

Accounts in Drug Discovery Volume 4725 || Chapter 3. The Discovery of Piragliatin, a Glucokinase Activator

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 11.25 MB

english, 2010

22

Detection of mutagen-induced lesions in isolated DNA using a new Bacillus subtilis transformation-based assay

Robert A. Phillips, Stanley A. Zahler, Anthony J. Garro

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1980

Langue:

english

Fichier:

PDF, 985 KB

english, 1980

23

Twice switched at birth: Cell cycle-independent roles of the “neuron-specific” cyclin-dependent kinase 5 (Cdk5) in non-neuronal cells

Johanna Liebl, Robert Fürst, Angelika M. Vollmar, Stefan Zahler

Journal:

Cellular Signalling

Année:

2011

Langue:

english

Fichier:

PDF, 531 KB

english, 2011

24

Assessment of human MAPCs for stem cell transplantation and cardiac regeneration after myocardial infarction in SCID mice

Ilias Dimomeletis, Elisabeth Deindl, Marc Zaruba, Michael Groebner, Stefan Zahler, Saskia M. Laslo, Robert David, Sawa Kostin, Markus A. Deutsch, Gerd Assmann, Josef Mueller-Hoecker, Michaela Feuring-

Journal:

Experimental Hematology

Année:

2010

Langue:

english

Fichier:

PDF, 1.19 MB

english, 2010

25

Ginkgo biloba extract EGb® 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases

Anja Koltermann, Johanna Liebl, Robert Fürst, Hermann Ammer, Angelika M. Vollmar, Stefan Zahler

Journal:

Journal of Cellular and Molecular Medicine

Année:

2009

Langue:

english

Fichier:

PDF, 763 KB

english, 2009

26

Accounts in Drug Discovery Volume 99 || Chapter 13. The Discovery of TRPV1 Antagonists: Turning up the Heat

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 1.22 MB

english, 2010

27

A novel approach to prevent endothelial hyperpermeability: The Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway

Martin F. Bubik, Elisabeth A. Willer, Peter Bihari, Guido Jürgenliemk, Hermann Ammer, Fritz Krombach, Stefan Zahler, Angelika M. Vollmar, Robert Fürst

Journal:

Journal of Molecular and Cellular Cardiology

Année:

2012

Langue:

english

Fichier:

PDF, 2.29 MB

english, 2012

28

Accounts in Drug Discovery || Chapter 14. Uncoupling Neuroprotection from Immunosuppression: the Discovery of ILS-920

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 6.45 MB

english, 2010

29

Strained aromatic systems. Synthesis of dicyclobuta[1,2:3,4]naphthalenes, dicyclobuta[1,2:3,4]anthracene, and tricyclobutabenzene

Doecke, Christopher W., Garratt, Peter J., Shahriari-Zavareh, Hooshang, Zahler, Robert

Journal:

Journal of Organic Chemistry

Année:

1984

Langue:

english

Fichier:

PDF, 842 KB

english, 1984

30

Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG

Brian J. Terry, Kathryn E. Mazina, A.Vickie Tuomari, Mary L. Haffey, Moira Hagen, Abbe Feldman, William A. Slusarchyk, Marian G. Young, Robert Zahler, A.Kirk Field

Journal:

Antiviral Research

Année:

1988

Langue:

english

Fichier:

PDF, 950 KB

english, 1988

31

The Crataegus extract WS® 1442 inhibits balloon catheter-induced intimal hyperplasia in the rat carotid artery by directly influencing PDGFR-β

Robert Fürst, Ute Zirrgiebel, Frank Totzke, Stefan Zahler, Angelika M. Vollmar, Egon Koch

Journal:

Atherosclerosis

Année:

2010

Langue:

english

Fichier:

PDF, 603 KB

english, 2010

32

Outcome of Combined Stenotic and Regurgitant Aortic Valve Disease

Zilberszac, Robert, Gabriel, Harald, Schemper, Michael, Zahler, David, Czerny, Martin, Maurer, Gerald, Rosenhek, Raphael

Journal:

Journal of the American College of Cardiology

Année:

2013

Langue:

english

Fichier:

PDF, 703 KB

english, 2013

33

Regulation of endothelial signaling and migration by v-ATPase

Rath, Sebastian, Liebl, Johanna, Fürst, Robert, Vollmar, Angelika M., Zahler, Stefan

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2014

34

Total synthesis of the polyether antibiotic ionomycin

Evans, David A., Dow, Robert L., Shih, Thomas L., Takacs, James M., Zahler, Robert

Journal:

Journal of the American Chemical Society

Année:

1990

Langue:

english

Fichier:

PDF, 3.53 MB

english, 1990

35

Synthesis and reactions of bicyclo[3.1.0]hexatrienes

Washburn, William N., Zahler, Robert, Chen, Ida

Journal:

Journal of the American Chemical Society

Année:

1978

Langue:

english

Fichier:

PDF, 1.67 MB

english, 1978

36

Phosphinyl Acid-Based Bisubstrate Analog Inhibitors of Farnesyl Protein Transferase

Patel, Dinesh V., Gordon, Eric M., Schmidt, Robert J., Weller, Harold N., Young, Marian G., Zahler, Robert, Barbacid, Mariano, Carboni, Joan M., Gullo-Brown, Johnni L., Hunihan, Lisa, Ricca, Carol, Ro

Journal:

Journal of Medicinal Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 2.15 MB

english, 1995

37

Chemistry of bicyclo[3.1.0]hexatriene

Washburn, William N., Zahler, Robert

Journal:

Journal of the American Chemical Society

Année:

1976

Langue:

english

Fichier:

PDF, 416 KB

english, 1976

38

The dianion of dimethyl cyclobut-3-ene-1,2-dicarboxylate. Aromaticity vs. Coulombic repulsion

Garratt, Peter J., Zahler, Robert

Journal:

Journal of the American Chemical Society

Année:

1978

Langue:

english

Fichier:

PDF, 289 KB

english, 1978

39

Deuterium labeling studies of bicyclo[3.1.0]hexatriene

Washburn, William N., Zahler, Robert

Journal:

Journal of the American Chemical Society

Année:

1976

Langue:

english

Fichier:

PDF, 270 KB

english, 1976

40

Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside

Bisacchi, Gregory S., Singh, Janak, Godfrey, Jollie D., Kissick, Thomas P., Mitt, Toomas, Malley, Mary F., Di Marco, John D., Gougoutas, Jack Z., Mueller, Richard H., Zahler, Robert

Journal:

Journal of Organic Chemistry

Année:

1995

Langue:

english

Fichier:

PDF, 547 KB

english, 1995

41

Reactions of alkyl substituted bicyclo[3.1.0]hexatriene

Washburn, William N., Zahler, Robert

Journal:

Journal of the American Chemical Society

Année:

1977

Langue:

english

Fichier:

PDF, 305 KB

english, 1977

42

Accounts in Drug Discovery || Chapter 11. 2′-F-2′-C-Methyl Nucleosides and Nucleotides for the Treatment of Hepatitis C Virus: from Discovery to the Clinic

Barrish, Joel, Carter, Percy, Zahler, Robert

Année:

2010

Langue:

english

Fichier:

PDF, 930 KB

english, 2010

43

Dimetallated Vicinal Diesters. Reaction with α,ω-Dihalides and Ditosylates; A New Method of Annelation for the Preparation of Bicyclo[x,y,0]alkanes

Bilyard, Kevin G., Garratt, Peter J., Zahler, Robert

Journal:

Année:

1980

Fichier:

PDF, 125 KB

1980

44

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3′,5′-Cyclic Adenosine 5′-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species

Fürst, Robert, Zahler, Stefan, Vollmar, Angelika M.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 259 KB

english, 2008

45

Bioanalysis of Pseudomonas aeruginosa alkyl quinolone signalling molecules in infected mouse tissue using LC–MS/MS; and its application to a pharmacodynamic evaluation of MvfR inhibition

Turnpenny, Paul, Padfield, Anthony, Barton, Patrick, Teague, Joanne, Rahme, Laurence G., Pucci, Michael J., Zahler, Robert, Rubio, Aileen

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2017

Langue:

english

Fichier:

PDF, 1.41 MB

english, 2017

46

Community-Based User Experience: Evaluating the Usability of Health Insurance Information with Immigrant Patients

Rose, Emma J., Racadio, Robert, Wong, Kalen, Nguyen, Shally, Kim, Jee, Zahler, Abbie

Journal:

IEEE Transactions on Professional Communication

Année:

2017

Langue:

english

Fichier:

PDF, 498 KB

english, 2017

47

Polypharmacology Approaches against the Pseudomonas aeruginosa MvfR Regulon and Their Application in Blocking Virulence and Antibiotic Tolerance

Maura, Damien, Drees, Steffen L., Bandyopadhaya, Arunava, Kitao, Tomoe, Negri, Michele, Starkey, Melissa, Lesic, Biliana, Milot, Sylvain, Déziel, Eric, Zahler, Robert, Pucci, Mike, Felici, Antonio, Fe

Journal:

ACS Chemical Biology

Année:

2017

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2017

48

Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia–Reperfusion

Praetner, Marc, Zuchtriegel, Gabriele, Holzer, Martin, Uhl, Bernd, Schaubächer, Johanna, Mittmann, Laura, Fabritius, Matthias, Fürst, Robert, Zahler, Stefan, Funken, Dominik, Lerchenberger, Maximilian

Journal:

Arteriosclerosis Thrombosis and Vascular Biology

Année:

2018

Langue:

english

Fichier:

PDF, 3.46 MB

english, 2018

49

Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus

Yamanaka, Gregory, Wilson, Todd, Innaimo, Steven, Bisacchi, Gregory S., Egli, Peter, Rinehart, J. Kent, Zahler, Robert, Colonno, Richard J.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1999

Langue:

english

Fichier:

PDF, 68 KB

english, 1999

50

Metabolic Studies on BMS-200475, a New Antiviral Compound Active against Hepatitis B Virus

Yamanaka, Gregory, Wilson, Todd, Innaimo, Steven, Bisacchi, Gregory S., Egli, Peter, Rinehart, J. Kent, Zahler, Robert, Colonno, Richard J.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1999

Fichier:

PDF, 68 KB

1999